TOP GUIDELINES OF PKRRATING

The interfacial residues are really conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations help a model the place activating RNA serves being a scaffold to bind a number of PKR monomers, rising

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